In addition, E.O. 13850, in conjunction with the conclusions of the Minister of Finance, authorizes sanctions against persons who would work in the gold, oil, finance and defence sectors of the Venezuelan economy and served as the basis for the appointment of the Venezuelan national oil company Petreoleos de Venezuela, S.A. (PdVSA) in January 2019. The Central Bank of Venezuela is also designated as E.O. 13850. During the evacuation of survivors of the Vargas tragedy, when torrential rains, floods and torrents of debris killed tens of thousands of people and destroyed thousands of homes in Vargas state in 2000, a U.S. disaster relief team led by New Mexico State Senator Joseph Carraro , met with a medical and humanitarian team to assess the damage and assist displaced people. Contact was made with the Alamos Laboratory in New Mexico to determine any radioactive activity in the debris field. Water treatment and sleep units were provided.  On March 12, 2019, the United States ceased operations at the Embassy in Caracas. The United States, through its U.S.-accredited ambassador, Carlos Vecchio, maintains formal diplomatic relations with Venezuela and the interim government of Guaido.
On 26 March 2020, the Ministry of Justice charged former President Maduro and 14 other current and former Venezuelan officials, including his vice-president in charge of the economy, his defence minister and the Supreme Court, with crimes related to drug terrorism, corruption, drug trafficking and other criminal charges. On April 5, 2019, the United States signed a power defense agreement with Switzerland to defend its interests in Venezuela, but the agreement is not yet in force because it has not been approved by Maduro`s government  because the United States has rejected Maduro`s proposal to have Turkey as a protective power. , since the United States recognizes Guaida as interim president.   Meanwhile, the United States has established a Venezuela Affairs Unit at the U.S. Embassy in Bogota, Colombia, to serve as the interim diplomatic office for Venezuela.  At the April 17, 2009 U.S. summit, he met Obama for the first time, only if he expressed his desire to become Obama`s friend.   Relations between the United States and Venezuela were even more strained when the country expelled the U.S. ambassador in September 2008 in solidarity with Bolivia, after a U.S. ambassador was accused of cooperating with violent anti-government groups in the country.
Although relations under President Barack Obama doped somewhat in June 2009, they gradually deteriorated shortly thereafter. In February 2014, the Venezuelan government ordered three US diplomats to accuse the violence   EU trade with Venezuela is affected by Venezuela`s ongoing economic crisis. Hugo Chavez has repeatedly claimed that the United States has a plan called “Plan Balboa” to conquer Venezuela.